Novel Continuous Reactors represent the next stage of manufacturing evolution, but bring a unique set of challenges.
Very short residence times test the limits of PAT instrumentation. High turn-down rates present a very broad range of 'normal' operating conditions. High feedstock costs impose limits on development and testing runs. The units are designed to run multiple different products, sometimes in multiple lots.
Working with the
Centre for Process Innovation (CPI), in a project co-sponsored by AstraZeneca, Perceptive Engineering developed the tools needed to fully exploit micro-reactors. Using results from off-line HPLC analysis and on-line MIR instrumentation, Perceptive produced a real-time estimate of product yield. This 'soft' sensor enabled control to be exercised more tightly, reducing testing time and providing a near-instant measurement of product quality.
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Our Clients & Partners
Selection of our clients and key partners we work with to improve process efficiency
Throughout development to manufacturing, data is key to enable rapid response to market demand. The knowledge to enable intelligent decisions and the wisdom to optimise the complete product lifecycle is now at your fingertips. The latest release of PerceptiveAPC v8.0 delivers the next
PD2M May 18-20 2021 Virtual This is the place to explore what pharmaceutical manufacturing will look like in 2030, sharing discussions on new ways to develop medicines. How will Industry 4.0 enable us to respond to market demand, delivering flexible, modular manufacturing and bringing
18-19 May 2021 Virtual Perceptive Engineering - an Applied Materials company - is looking forward to participating in the Bionow Pharma Manufacturing Conference 2021. We will be joining AstraZeneca and Bristol Meyers Squibb in session 2, discussing the ‘Digitisation of Pharma